Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives
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چکیده
منابع مشابه
Naloxegol increases frequency of bowel movements and combats inadequate response to laxatives.
Context The therapeutic action of opioid analgesics is compromised by peripheral adverse effects, among which constipation is the most disabling, as laxatives often fail to provide satisfactory relief. To address this problem, opioid receptor antagonists with limited systemic bioavailability (retarded naloxone) or a peripherally restricted site of action (alvimopan, methylnaltrexone) have been ...
متن کاملNaloxegol for opioid-induced constipation in patients with noncancer pain.
BACKGROUND Opioid-induced constipation is common and debilitating. We investigated the efficacy and safety of naloxegol, an oral, peripherally acting, μ-opioid receptor antagonist, for the treatment of opioid-induced constipation. METHODS In two identical phase 3, double-blind studies (study 04, 652 participants; study 05, 700 participants), outpatients with noncancer pain and opioid-induced ...
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ژورنال
عنوان ژورنال: Evidence Based Medicine
سال: 2014
ISSN: 1356-5524,1473-6810
DOI: 10.1136/ebmed-2014-110071